DOX Centre for Contemp. Art
It’s worth the trip out to the up-and-coming Holesovice to experience the modern side of old-world Prague, not to mention the travelling collections of world class art that the DOX Centre for Contemporary Art attracts. While you’re there, don’t forget to pop into the shop, which is almost as good as the museum. Exhibitions are always changing, so check the website for details of what’s on (and how much is on, for sometimes the space can appear rather empty between shows).