DNA Lounge is not only one of the best nightclubs in San Francisco to dance all night to the latest tunes, it is a also little piece of San Francisco’s modern dot-com history, thanks to its owner, Jamie Zawinski, who was one of the first faces at Netscape, helping to bring the Internet revolution to the people back around 1994-95. As you might expect, the place is genuinely cutting-edge cool, not trumped-up mainstream. The décor is sparse, the sound system is Goliath, the crowd varies depending on the show but is always ready to dance, and the shows include everything from strange new bands to world-famous DJs. A wicked sound system, an energetic crowd, and great music make this one of the best places in town to dance into the wee hours. Party people, go-go dancers, and other mainstays of the urban dance tribe hit DNA Lounge ready to get down to some serious booty shaking. On Friday nights and many Saturdays, they keep things moving until 5am, so if you get a late start on the night, this is your ticket.